Year: 2025
Type: article
Abstract: In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.
Authors: Steffen Löck, Lydia Koi, Kristin Gurtner, Fabian Lohaus, Max Kemper, Dominik Haim, Inge Tinhofer, Goda Kalinauskaite, Martin Stuschke, Maximilian Fleischmann, Claus Rödel, Anca-Ligia Grosu, Jürgen Debus, Claus Belka, Stephanie Combs, Simon Boeke, Gustavo Baretton, Michael Baumann, Mechthild Krause, Annett Linge
Institutions: German Cancer Research Center, Helmholtz-Zentrum Dresden-Rossendorf, OncoRay, University Hospital Carl Gustav Carus, Nationales Centrum für Tumorerkrankungen Dresden, German Cancer Consortium (DKTK) Dresden, Technische Universität Dresden, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Deutsches Konsortium für Translationale Krebsforschung, Charité - Universitätsmedizin Berlin, University of Duisburg-Essen, Goethe University Frankfurt, University of Freiburg, University Medical Center Freiburg, Heidelberg University, National Center for Tumor Diseases, Helmholtz Munich, LMU Klinikum, Ludwig-Maximilians-Universität München, Technical University of Munich, Universitätsklinikum Tübingen, University of Tübingen
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,430
OpenAlex ID: W4415942969