Work

Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing

Year: 2025

Type: article

Abstract: sepsis. Unexpectedly, Tgr5-deficient macrophages show reduced glycolysis and ATP citrate lyase expression, which cumulates in acetyl-CoA deficiency and impaired metabolic-epigenetic gene silencing, driving macrophages toward a hyperinflammatory phenotype during bacterial sepsis.

Source: iScience

DOI: 10.1016/j.isci.2025.113929

Authors: Maria Reich, Tobias Franz, Haifeng C. Xu, Paulina Philippski, Jan Stindt, Sandra Freier, Anja Sammt, Kristina Schoonjans, Philipp A. Lang, Sascha Kahlfuß, Verena Keitel

Institutions: University Hospital Magdeburg, Otto-von-Guericke-Universität Magdeburg, Heinrich Heine University Düsseldorf, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Deutsche Forschungsgemeinschaft, Else Kröner-Fresenius-Stiftung, Medizinische Fakultät, Universität Duisburg-Essen

Award: G2375482703

OpenAlex ID: W4415943582

FWCI: 4.877

Cites: 27

Cited by: 8

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