Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice
Year: 2025
Type: article
Abstract: deficiency and the consequent alteration of cerebellar microglia were associated with reduced mutual interactions, altered Purkinje cell morphology and electrophysiological activity, decreased molecular layer width, and subsequently defects in motor balance and coordination. Collectively, this study provides insights into the molecular mechanisms underlying microglia-neuron interaction within the cerebellum.
Source: iScience
Authors: Xiaoheng Li, Pin Yang, Binbin Dong, Lingling Jiang, Ruilian Xiu, Jia Guo, Shuoshuo Li, Ping Zhang, Runze Gu, Ao Li, Jinyu Zhang, Rong Wu, Fengchao Wang, Ying Shen, Ningsheng Shao, Jinbo Cheng, Zengqiang Yuan
Institutions: Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, Anhui Medical University, Sir Run Run Shaw Hospital, Zhejiang University, Southern Medical University, Hebei Medical University, Minzu University of China, Beijing University of Chinese Medicine, University of Chinese Academy of Sciences, University of South China, National Institute of Biological Sciences, Beijing
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
OpenAlex ID: W4415943644