A curcumin-enabled ZIF8 nanosystem enables ovarian cancer treatment by inducing mitochondrial disruption
Year: 2025
Type: article
Abstract: Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging. The advent of the Zeolitic Imidazolate Framework (ZIF) system offers a novel approach for antitumor drug delivery. In this study, effective drug delivery to ovarian cancer cells was accomplished through the construction of a ZIF-based nanodrug delivery system, ZIF-Cur, that encapsulates curcumin. We verified that Cur delivered by ZIF enhanced mitochondrial ROS accumulation in tumor cells, thereby killing tumor cells. The system showed the well biosafety profile, offering a insight therapeutic perspective for ovarian cancer treatment.
Source: Discover Nano
Authors: Zhishan Zhang, Genghui Luo, Xiaoxia Tang, Xiubin Ma, Weitao Huang, Bin Wang, Xueying Meng, Caiyan He, Xiaoman Cai, Ping Zhang, Shiyou Luo
Institution: Longgang Central Hospital
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,090
OpenAlex ID: W4415945744