Work

The rare lifeline: struggle and strategy behind Oh (Bombay) blood group transfusions

Year: 2025

Type: article

Abstract: 1. The case depicts the management of rare blood group [O h (Bombay)] emergency transfusion support in postoperative oncology patient. 2. The case highlights the need to establish a well-organized rare blood group donor registry as well as streamline procurement process. The O h (Bombay) blood group is a rare autosomal recessive gene characterized by absence of H-antigen, severely restricting transfusion options due to scarce compatible donors. A 61-year female with advanced endometrial cancer and rare O h (Bombay) blood group faced significant transfusion challenges due to postoperative complications and scarcity of blood components. Despite exhaustive efforts, including rare donor mobilization and transfusion of multiple blood components, securing O h (Bombay) units remained a significant and persistent challenge throughout the course of management. This case emphasizes the urgent need for structured registries, coordinated logistics, and expert strategies in rare blood group transfusion care.

Source: Blood Global Hematology

DOI: 10.1016/j.bglo.2025.100044

Authors: Aditi Khanna, Bhagyashri Surve, Suryatapa Saha, Shashank Ojha, Chitra Dewanji, Surangma Singh

Institutions: Homi Bhabha National Institute, Tata Memorial Hospital, Advanced Centre for Treatment, Research and Education in Cancer

Language: English

Topic: Blood groups and transfusion

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000