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Long non‑coding RNA RP11‑196G11.6 inhibits neuroblastoma progression by regulating the miR‑376a‑3p/RYBP signaling axis

Year: 2025

Type: article

Abstract: cells. Mechanistically, RP11-196G11.6 directly inhibited miR-376a-3p, which targeted RYBP. Overexpression of miR-376a-3p reversed the tumor suppressor phenotype driven by RP11-196G11.6. In summary, the present study demonstrated that RP11-196G11.6 may inhibit NB progression by sponging miR-376a-3p, leading to the upregulation of RYBP expression and consequently inhibiting NB progression. These findings revealed a novel lncRNA-miRNA axis involved in NB pathogenesis.

Source: Oncology Letters

DOI: 10.3892/ol.2025.15376

Authors: Jie Zhang, Kai Huang, Jianwu Zhou, Wenge Liao, Fei Li, Zhenzhen Zhao, Shan Wang

Institutions: Children's Hospital of Chongqing Medical University, Chongqing Medical University, Guizhou Provincial People's Hospital

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415947276

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