Assessment of lixisenatide-induced nephropathy in chick embryos: Implications for prevention of diabetic kidney disease
Year: 2025
Type: article
Abstract: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and the direct renal effects of GLP-1 receptor agonists remain underexplored. Using a hyperglycemic chick embryo model (n=120), we evaluated dose-dependent nephroprotective effects of lixisenatide. Hyperglycemia induced renal hypertrophy, histological injury, oxidative stress, inflammation and apoptosis. Lixisenatide, particularly at high doses, significantly ameliorated these changes, normalizing kidney-to-body ratios and reducing MDA, TNF-α and caspase-3 activity. Thus, we show that lixisenatide directly preserves renal structure and function independent of systemic metabolic control.
Source: Bioinformation
Authors: Amit Kumar Srivastava, Aishwarya Srivastava, Rohini Srivastava, Swati Yadav, Jyoti Batra, Yogesh Yadav
Institutions: Santosh University, Saraswathi Institute of Medical Sciences
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415948030
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