Work

NeuroSpikeX: Comprehensive detection and characterization of neuronal calcium dynamics

Year: 2025

Type: software-paper

Abstract: NeuroSpikeX is a user-friendly tool for the quantitative analysis of neuronal calcium dynamics. It provides robust calcium spike detection, comprehensive network metrics, and intuitive graphical interfaces. NeuroSpikeX seamlessly integrates into existing workflows using outputs from the established algorithm NeuroCa, enhancing accuracy and reproducibility. The code effectively analyzes calcium dynamics across numerous in vitro datasets containing multiple experimental time points. NeuroSpikeX facilitates detailed cell and network analyses in large datasets, making rigorous calcium transient characterization accessible to researchers with minimal coding expertise.

Source: SoftwareX

DOI: 10.1016/j.softx.2025.102435

Authors: J.A. Sergay, A. Hai, C. Franck

Institution: University of Wisconsin–Madison

Language: English

Topic: Cell Image Analysis Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,200

Funder: Office of Naval Research