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Thiophene-based water-soluble C70 fullerene derivatives as novel antioxidant agents.

Year: 2025

Type: article

Abstract: fullerene derivatives with thiophene-based solubilising addends and tested their cytotoxicity and the transcriptional activity of genes, which regulate an oxidative metabolism. Aliphatic chain length in the structure of the solubilising addend of the water-soluble fullerene derivative has been varied, and we revealed that a longer chain resulted in more pronounced antioxidant activity. Thus, the surface modification enhances the antioxidant properties of the compound and changes the nanoparticles impact on the genetic apparatus of the cell. Interestingly, even slight modifications of the functional addend's structure can significantly affect the final cell response. The data obtained can be harnessed to develop novel and efficient medications for the management of ischaemia, stress-related conditions, the prevention of ageing, and the resolution of other practical healthcare challenges.

Source: PubMed

Authors: Margarita Chetyrkina, Pavel Umriukhin, Elizaveta Ershova, Elena Proskurnina, Vasilina Sergeeva, Ekaterina Savinova, Svetlana E Kostyuk, Larisa Kameneva, Olga Kraevaya, Valeriya Bolshakova, Pavel Troshin, Tatiana Salimova, Ivan Rodionov, Sergey Kutsev, Natalia Veiko, Svetlana V Kostyuk

Institutions: National Research University Higher School of Economics, Sechenov University, Research Centre for Medical Genetics, Institute of Problems of Chemical Physics

Language: English

Topic: Fullerene Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4415958680

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