Work

Enabling global access to potent subunit vaccines with a simple and scalable injectable hydrogel platform

Year: 2025

Type: article

Abstract: , and synchronize release kinetics across physicochemically distinct vaccine components (antigens and adjuvants). When used for formulation of subunit vaccines against wild-type SARS-CoV-2 and H5N1 influenza, these hydrogels enhance potency and durability of immune responses. This vaccine formulation technology can improve protection against current and potential future pandemic pathogens.

Source: Biomaterials Science

DOI: 10.1039/d5bm01131k

Authors: Priya Ganesh, Alexander N. Prossnitz, Carolyn K. Jons, Noah Eckman, Alakesh Alakesh, Ye Eun Song, Samya Sen, Eric A. Appel

Institutions: Stanford University, Stanford Medicine

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Bill and Melinda Gates Foundation, National Institutes of Health, Stanford Maternal and Child Health Research Institute

Awards: 30-parameter FACSymphony A3 flow cytometer for Shared Resource Lab, Graduate Research Fellowship Program (GRFP), G2911450482, Stanford University - to use hydrogel sustained release vaccine formulation to reduce a multi-dose vaccine regimen to a single-dose vaccine regimen

OpenAlex ID: W4415958780

FWCI:

Cites: 52

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