Work

PurFect timing: revisiting purine metabolism for tuberculosis treatment

Year: 2025

Type: article

Abstract: Eradication of tuberculosis requires new drugs targeting novel pathways. Although purine metabolism represents an essential antitubercular target, concerns about host nucleobase rescue limited its exploration. New data demonstrate that nucleobase levels in human lung tissue are insufficient to confer rescue, renewing interest in this pathway for tuberculosis drug discovery.

Source: Trends in Microbiology

DOI: 10.1016/j.tim.2025.10.010

Authors: Richard J. Wall, Valerie Mizrahi, Dirk A. Lamprecht

Institutions: London School of Hygiene & Tropical Medicine, University of Cape Town, Institute of Infectious Disease and Molecular Medicine

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030