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Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis

Year: 2025

Type: article

Abstract: In this issue of Stem Cell Reports, Schmitz, Okamura et al. manipulate enhancer elements of the endogenous Oct4 locus to investigate consequences on Oct4 expression and cell fate. While their findings confirm some previous results, they also identify interesting discrepancies from earlier studies using conventional reporters or total Oct4 knockouts.

Source: Stem Cell Reports

DOI: 10.1016/j.stemcr.2025.102705

Authors: Lawrence E. Bates, Jennifer Nichols

Institutions: Western General Hospital, Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Edinburgh

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,190

OpenAlex ID: W4415965296

FWCI:

Cites: 10

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