Work

Nicolau Syndrome following Benzathine Benzylpenicillin Injection in a Patient with Syphilis and Type 2 Diabetes: A Case Report

Year: 2025

Type: article

Abstract: Introduction: Nicolau syndrome (NS) is a rare complication following intramuscular (IM), intra-articular, or subcutaneous injections, marked by severe localized pain, skin discoloration, and tissue necrosis. Treatments focus on halting causative agents, pain control, and preventing secondary infections. Here we describe a case of NS due to the use of penicillin G benzathine for syphilis. Case Presentation: A 39-year-old male presented with a painful rash on his left buttock 3 min after IM injection of penicillin G benzathine for the treatment of syphilis. The patient, with a history of type 2 diabetes, experienced significant complications including rhabdomyolysis and liver dysfunction. After the treatment of corticosteroids, anticoagulation, fluid resuscitation, and alkalinizing the urine, the patient recovered well. Conclusion: NS may result from accidental arterial injection (causing vascular occlusion) or hypersensitivity reactions to medications. We reported the clinical course of a case of NS and highlight the need for proper injection technique, early intervention, and multidisciplinary care to manage NS and its complications.

Source: Case Reports in Dermatology

DOI: 10.1159/000548557

Authors: Yuyan Cheng, Yiwen Mao, Jingwen Wang, Xin Du

Institutions: Anhui Medical University, Second Affiliated Hospital of Anhui Medical University

Language: English

Topic: Intramuscular injections and effects

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030