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Elevated Transaminases Revealing Celiac Disease in a Patient With Normal Gastrointestinal Symptoms in a Tertiary Healthcare Setting: A Case Report

Year: 2025

Type: article

Abstract: Celiac disease (CD) is a lasting immune disease, most commonly with gastrointestinal symptoms; nonetheless, atypical symptoms of non-digestive tracts have now increasingly become common. We report the case of a 28-year-old woman with a history of constantly increased transaminases and no gastrointestinal symptoms. An extensive hepatic etiology testing was of no note. CD was diagnosed through the presence of positive anti-tissue transglutaminase IgA and duodenal biopsy. There was a great improvement, including liver enzyme normalization, in three months of a gluten-free diet. This case showed the necessity to consider CD as part of the diagnostic process of unexplained hypertransaminasemia despite the lack of gastrointestinal symptoms. Preventive measures of hepatic progression to widespread involvement and an increase in long-term prognosis can be achieved through dietary intervention and early diagnosis.

Source: Cureus

DOI: 10.7759/cureus.96240

Authors: Farya Mughal, Ahmad Munib, Amanullah Khan

Institutions: Shaikh Zayed Hospital, University of the Punjab, University of Health Sciences Lahore

Language: English

Topic: Celiac Disease Research and Management

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415971223