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Yellow-eyed man and dromomania: A case of adult-onset psychiatric symptoms in Crigler–Najjar syndrome type II

Year: 2025

Type: article

Abstract: A 30-year-old man presented with long-standing, treatment-resistant psychiatric symptoms including compulsive wandering, hallucinations, and obsessive behaviors. Physical examination revealed deep yellow sclera present since childhood. Genetic testing identified compound heterozygous mutations in the UGT1A1 gene, confirming Crigler–Najjar syndrome type II. Initiation of phenobarbitone and adjunctive therapy led to a marked reduction in serum bilirubin and clinical symptoms. This case highlights the possibility of bilirubin-induced neurological dysfunction presenting in adulthood as a chronic psychiatric condition.

Source: Adesh University Journal of Medical Sciences & Research

DOI: 10.25259/aujmsr_62_2025

Authors: Kamal Kishore Pandita, Anupama Shah

Institutions: Government Medical College, Government Medical College

Language: English

Topic: Neonatal Health and Biochemistry

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415982129