Work

Preparation and evaluation of lactoferrin-modified curcumin long-circulating nanoliposomes for hypoxic brain injury therapy

Year: 2025

Type: article

Abstract: with Lf-Cur-LCL significantly increasing Cur content in brain tissues. Furthermore, Cur-L, Cur-LCL, and Lf-Cur-LCL increased the partial pressure of oxygen and decreased the partial pressure of carbon dioxide in chronic intermittent hypoxia model mice. These formulations also elevated levels of superoxide dismutase and reduced malondialdehyde levels in the model group. Furthermore, they also demonstrated a reparative effect on liver, brain, and spleen damage induced by the model, with Lf-Cur-LCL showing the most significant therapeutic effect. In conclusion, the prepared Lf-Cur-LCL exhibited brain-targeting properties and showed considerable potential for treating brain diseases, thus providing theoretical support for clinical development and application of curcumin.

Source: Nanoscale Advances

DOI: 10.1039/d5na00521c