Work

Pharmacological and Interventional Prevention and Treatment of Microvascular Obstruction Following Primary PCI in STEMI

Year: 2025

Type: article

Abstract: Microvascular obstruction (MVO) accounts for up to 50% of patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The pathogenesis is multifactorial and includes myocardial ischemia, distal embolization, and ischemia-reperfusion injury, in a context of individual susceptibility. Its occurrence has been related to adverse outcomes. Despite an extensive body of research, no single pharmacological or interventional strategy has proven effectiveness. The inconclusive nature of the evidence can be attributed to lack of standardization among studies in terms of drugs used and their dosage, the variability in study designs, and the fact that available studies performed a decade ago feature reperfusion strategies and drugs used that differ significantly from the current standard of care. In this context, our review aims to discuss the pharmacological and interventional approaches to MVO.

Source: Journal of Cardiovascular Development and Disease

DOI: 10.3390/jcdd12110440

Authors: Giovanni Occhipinti, Michele Strosio, Riccardo Rinaldi, Andrea Ruberti, Salvatore Brugaletta

Institutions: Hospital Clínic de Barcelona, Universitat de Barcelona, University of Padua

Language: English

Topic: Acute Myocardial Infarction Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258