Work

Redox and apoptosis modulation by telmisartan, ertugliflozin, and omaveloxolone in a rat model of global cerebral ischemia/reperfusion injury

Year: 2025

Type: article

Abstract: Ischemic stroke, accounting for 87% of all stroke cases, is a major global health issue associated with global cerebral ischemia. This study aimed to evaluate the neuroprotective effects of telmisartan, ertugliflozin, and omaveloxolone on cerebral ischemia–reperfusion injury. Forty-two rats were randomly assigned to seven groups. Their brain tissues were collected for infarct size assessment using triphenyltetrazolium chloride (TTC) staining and for ELISA analysis of oxidative and apoptotic markers, including superoxide dismutase (SOD), catalase (CAT), caspase-3, BCL2-associated protein X (BAX), B cell lymphoma-2 (BCL2), and the BCL2/BAX ratio. Pretreatment significantly reduced infarct area ( P < 0.05), as determined by TTC staining. All three treatments significantly increased antioxidant enzyme levels, including SOD and CAT ( P < 0.05). The treated groups showed a substantial decrease in caspase-3 levels, increased BCL2 expression, and a higher BCL2/BAX ratio ( P < 0.05). Telmisartan, ertugliflozin, and omaveloxolone each produced neuroprotective benefits, preserving brain tissue largely through their antioxidant and anti-apoptotic actions.

Source: Pharmacia

DOI: 10.3897/pharmacia.72.e169142

Authors: Yasser J. H. Alyassery, Ahsan F. Bairam

Institution: University of Kufa

Language: English

Topic: Neurological Disorders and Treatments

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107