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Normative Data of Sensory and Motor Nerve Conduction Parameters: Gender-based Differences and Effect of Age and Height in Healthy Population of Himachal Pradesh

Year: 2025

Type: article

Abstract: Background: Nerve conduction studies are a common clinical investigation for evaluating peripheral nerve abnormalities. Various sets of normal values exist; ideally, each laboratory should establish its own set of normal values. Purpose: Develop normative data of nerve conduction study (NCS) studies for upper and lower limbs. Methods: Nerve conduction studies were conducted on the upper and lower extremities of meticulously screened, healthy participants of both genders, among the Himachal and Punjab population, using Natus Synergy on Nicolet TM EDX EMG/NCV/EP system. They were all within the age range of 20-60 years. Velocities were calculated by onset latencies, and amplitudes were measured from baseline to the negative peak. Descriptive statistics were computed. Mann-Whitney U tests were used to look for the effect of gender. Linear regression was used to evaluate the effect of age and height. Results: The study population include 50 males and 50 females. The age and body mass index (BMI) of subjects were similar across gender. Proximal motor latency (Right (R) & Left (L) Median and Ulnar, R tibial, R Peroneal), Distal motor latency (L median, peroneal), sensory onset and peak latencies (R&L ulnar nerves) were significantly longer in males as compared to females. Motor NCV (L Median, R Ulnar, R&L Tibial and Peroneal), compound muscle action potential (CMAP) Amplitude (R&L Median, Tibial, Peroneal and R ulnar), Sensory NCV (R Median, L Ulnar), sensory nerve action potential (SNAP) amplitude (R&L median and ulnar) were significantly decreasing with age. Conclusion: This study established normative conduction parameters of commonly tested nerves of the upper and lower limbs. investigated the effects of age, gender and height for our clinical neurophysiology laboratory.

Source: Annals of Neurosciences

DOI: 10.1177/09727531251383207