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Primary Graft Dysfunction Following Heart Transplantation: A Modern Review of Primary Graft Dysfunction

Year: 2025

Type: article

Abstract: Primary graft dysfunction (PGD) represents a poor prognostic outcome for patients undergoing orthotopic heart transplantation (OHT). The risk factors associated with PGD are multifactorial and complex, encompassing factors related to the donor, recipient, and preservation. The early expansion of donation after circulatory death (DCD) donors has also resulted in an increased incidence of PGD. This paper aims to review the pertinent literature on the risk factors, patient outcomes, and trends of PGD post-OHT. Further discussion regarding PGD following DCD from an OHT, the treatment of PGD, and current efforts to decrease PGD are also explored.

Source: The Heart Surgery Forum

DOI: 10.31083/hsf47709

Authors: Brandon E. Ferrell, Jason Thomas, Madison McFarland, Adam D. Chalek, Mirkelis De Jesus Martinez, Korri S. Hershenhouse, Tadahisa Sugiura

Institutions: Montefiore Medical Center, Albert Einstein College of Medicine

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415994439

FWCI:

Cites: 60

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