Risk for severe refractory Mycoplasma pneumoniae pneumonia complicated with bronchitis obliterans among children
Year: 2025
Type: article
Study design: Observational Study
Abstract: To investigate the independent risk factors for severe refractory MP pneumonia (SRMPP) complicated by bronchitis obliterans in children. A retrospective analysis was conducted on the clinical data of children with SRMPP admitted to the Department of Pediatrics from October 2022 to October 2024 in Linping branch the Second Affiliated Hospital of Zhejiang University. Differences in clinical characteristics between the 2 groups were compared. Multivariate logistic regression identified independent risk factors for SRMPP complicated with bronchitis obliterans, and receiver operating characteristic curve analysis evaluated. A total of 120 children with SRMPP were included, multivariate logistic regression analysis revealed that elevated D-dimer (D-D) levels (OR: 2.46, 95% CI: 1.41-4.81), elevated ferritin levels (OR: 2.93, 95% CI: 1.68-5.90), and the plastic mucus plugs (OR: 6.32, 95% CI: 4.32-9.64) were independent risk factors for SRMPP complicated with bronchitis obliterans (P < .01), while high serum albumin levels (OR: 0.82, 95% CI: 0.64-0.92) served as an independent protective factor (P = .01). Receiver operating characteristic curve analysis demonstrated that the areas under the curve for predicting bronchitis obliterans were 0.68 for elevated D-D, 0.66 for elevated ferritin, 0.72 for decreased albumin, and 0.70 for plastic mucus plugs. Elevated D-D, ferritin, and plastic mucus plugs are bronchitis obliterans risk factors in SRMPP children, high albumin is protective.
Source: Medicine
Authors: Zhonghua Hu, Chengchao Fang
Institution: Second Affiliated Hospital of Zhejiang University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,950
OpenAlex ID: W4416011078