Work

Low- Q Asymptotic Behavior of the Effective Structure Factor Yields Model-Independent Radius of Interparticle Interaction ( R i )

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Guinier analysis has been extensively used in academic and industrial research settings to obtain the model-independent size of a polymer, protein, or colloid in solution from small-angle scattering data. Using the Guinier model, the radius of gyration ( R g ) is extracted from the form factor at low Q . Here, we develop an analogous approach for analyzing the effective structure factor data at low Q to extract a model-independent radius of interaction potential, R i . Whereas R g describes how spread out the scattering length density distribution of particles is from their center of mass, R i is an effective root-mean-square distance that quantifies how far the interparticle correlation deviates from its ideal gas configuration due to interactions. We demonstrate this novel analysis method by applying it to experimental small-angle neutron scattering data on lysozyme protein solutions. We discuss its broad implications for analysis of low- Q asymptotic X-ray and neutron scattering data, where Guinier analysis is traditionally applied.

Source: ACS Measurement Science Au

DOI: 10.1021/acsmeasuresciau.5c00099

Authors: Chelsea E. R. Edwards, Wellington C. Leite, Yun Liu

Institutions: National Institute of Standards and Technology, NIST Center for Neutron Research, Oak Ridge National Laboratory, University of Delaware

Language: English

Topic: Nuclear Physics and Applications

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,500