Work

PINK1/Parkin promotes liver regeneration via Sigma-1 ubiquitination to inhibit ER-Mitochondrial calcium transfer

Year: 2025

Type: article

Abstract: Collectively, PINK1/Parkin signaling regulates hepatocellular mitochondrial ATP and succinate production by modulating ER-mitochondria calcium transfer to promote liver regeneration, revealing a promising therapeutic target for liver regeneration.

Source: Theranostics

DOI: 10.7150/thno.115726

Authors: Jian Xu, Yuechen Wang, Weizhe Zhong, Haoran Hu, Ye Zhang, Yiyun Gao, Ping Wang, Zhuqing Rao, Haoming Zhou, Xuehao Wang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Jiangsu Province Hospital, Nanjing Medical University

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4416016121

FWCI: 1.49

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Cited by: 3

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