Engineered nanoconjugates for simultaneous detection and degradation of stroke-associated microthrombi
Year: 2025
Type: article
Abstract: IO@PDA@tPA represents a promising theranostic agent targeting microthrombi in AIS, reducing the required r-tPA dose and limiting associated side effects.
Source: Theranostics
DOI: 10.7150/thno.119705
Authors: Audrey Picot, Charlène Jacqmarcq, Célia Seillier, Sara Martinez de Lizarrondo, Maxime Gauberti, Ankita Talukdar, Igor Khalin, Clarisse Mouriaux, Pierre Mangin, Didier Goux, Peter Schmidt, Denis Vivien, Thomas Bonnard
Institutions: Inserm, Normandie Université, Cyceron, Physiopathologie et imagerie des troubles neurologiques, Université de Caen Normandie, Centre Hospitalier Universitaire de Caen Normandie, LMU Klinikum, Institut für Schlaganfall- und Demenzforschung, Ludwig-Maximilians-Universität München, Biologie et pharmacologie des plaquettes sanguines : hémostase, thrombose, transfusion, Université de Strasbourg, CSL (Australia)
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
Funder: Agence Nationale de la Recherche
OpenAlex ID: W4416016147