Work

Mertk promotes early microglial-mediated synaptic engulfment in Alzheimer's disease

Year: 2025

Type: article

Abstract: Collectively, our findings suggest that PPARγ-regulated, Mertk-mediated microglial synaptic engulfment contributes to early synaptic loss in AD, highlighting microglial Mertk as a potential therapeutic target for AD.

Source: Theranostics

DOI: 10.7150/thno.116797

Authors: Yifan Wu, Yuanteng Fan, Shisan Bao, Yinghao Song, Ruizhu Wang, Jiaxuan Wu, Xuan Liu, Jingwen Jin, Lingchen Kong, Baohua Hou, Peiyu Liang, Taoxiang Chen, Wanhong Liu, Biwen Peng, Fanggang He, Ying Zhou, Jian Xu, Yun Chen, Song Han, Jun Yin, Xiaohua He

Institutions: Wuhan University, Zhongnan Hospital of Wuhan University, The University of Sydney, Henan Polytechnic University, Weifang Maternity and Child Care Hospital

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4416016152

FWCI: 0.296

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Cited by: 1

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