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Nuclear deformation acts as a mechanical switch to drive breast cancer cell migration in a confined microenvironment

Year: 2025

Type: article

Abstract: This study demonstrates the fundamental importance of nuclear deformation and mechanotransduction in cancer cell migration, providing new perspectives for the development of therapeutic approaches that target nuclear mechanics to inhibit metastatic progression.

Source: Theranostics

DOI: 10.7150/thno.119211

Authors: Meng Wang, Xiaodie Li, Boyang Li, Hanyu Guo, Zihan Zhao, Xiyue Sun, Wei Yan, Yubo Tan, Jinyi Liu, Yungchang Chen, Shun Li, Tingting Li, Xiaozhen Dai, Xiang Qin, Yiyao Liu

Institutions: University of Electronic Science and Technology of China, Sichuan Cancer Hospital, Chengdu Medical College, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4416016156

FWCI: 1.683

Cites:

Cited by: 4

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