Work

Downregulation of PCYT2 by increased portal pressure safeguards liver regeneration after partial hepatectomy

Year: 2025

Type: article

Abstract: Decreased PCYT2 levels and PE content due to increased portal pressure protect hepatocytes from PHx-induced injury. Inhibiting PCYT2 with NP-meclizine promoted normal liver regeneration in middle-aged mice.

Source: Theranostics

DOI: 10.7150/thno.118755

Authors: Guangyin Pu, Yayue Song, Qiushi Li, Jinjie Duan, Guangyan Wang, Wenjing Xiu, Jingwen Xu, Xiaoyu Zhao, Wenhui Dong, Tingting Lan, Rong Ai, Jingyi Zhang, Weiyan Sun, Deling Kong, Yi Zhu, Xu Zhang, Yang Liu, Chunjiong Wang

Institutions: Tianjin Medical University, Imperial College London, Nankai University, State Key Laboratory of Medicinal Chemical Biology, Tianjin First Center Hospital, Peking University

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4416016201

FWCI: 0.485

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Cited by: 1

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