Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells
Year: 2025
Type: article
Abstract: A modification of their mRNAs and reducing their mRNA stability. In mouse models of cancer, combining FTO knockdown with ibrutinib markedly suppressed tumor growth, decreased metastasis, and improved survival. Collectively, the combined inhibition of FTO and BTK exhibited substantial synergistic anticancer effects in breast cancer. Our findings advocate for the evaluation of this combination in clinical trials.
DOI: 10.7150/ijbs.117999
Authors: Abdulaziz Ahmed A. Saad, Lichen Ge, Haoran Wang, Yan Xia, Jianing Li, Shiyao Qiao, Cheng Yi, Xiansong Wang, Zhaotong Wang, Dan Zhou, Hongsheng Wang
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4416016285