Work

Electrochemical determination of paclitaxel using a poly(3-nitro-L-tyrosine)/WC NPs modified gold electrode

Year: 2025

Type: article

Abstract: Given critical therapeutic role and formulation challenges for paclitaxel, the accurate quantification of PAC in pharmaceutical products and biological samples is of great importance. In this study, we developed a novel electrochemical sensor by electropolymerizing 3-nitro tyrosine on a gold electrode, followed by modification with tungsten carbamide (WC) nanoparticles to enhance conductivity and surface area. Scanning electron microscopy confirmed a uniform nanostructured coating with high electroactive surface roughness. The fabricated P3NLT/WC/AuE sensor exhibited a distinct oxidation signal at −1.13 mV, which shifted positively upon interaction with PAC, indicating a selective recognition process between the polymeric layer and the drug. Using differential pulse voltammetry, the sensor displayed a broad linear dynamic range (1.33E-09 mol.L -1 to 5.42E-06 mol.L -1 ) and an ultra-low detection limit of 1.20E-11 mol.L -1 . The applicability of the developed platform was validated through the determination of PAC in commercial injection formulations, achieving recovery rates between 99.01% and 101.02%. These results highlight the P3NLT /WC/AuE sensor as a promising, sensitive, and selective analytical tool for pharmaceutical quality control and therapeutic drug monitoring of paclitaxel in clinical practice.

Source: International Journal of Electrochemical Science

DOI: 10.1016/j.ijoes.2025.101223

Authors: Basima A.A. Saleem, Amer Th. Al-Taee, Salim A. Mohammed

Institution: University of Mosul

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,670