Work

Antibacterial efficacy of γ‐mangostin against Xanthomonas campestris via disruption of cell morphology and virulence functions

Year: 2025

Type: article

Abstract: BACKGROUND: Bacterial diseases pose significant threats to crop production. Natural products offer promising alternatives due to their structural diversity, low toxicity, and reduced resistance potential for controlling plant bacterial diseases. Xanthomonas campestris pv. campestris (Xcc) is the causal agent of black rot disease in cruciferous vegetables, yet effective natural products for managing black rot have not been thoroughly explored. RESULTS: of 6.48 ± 1.07 μg/mL. We observed that γ-mangostin exhibits strong antibacterial activity, significantly reduces the virulence of Xcc, and provides both protective and curative effects against crucifer black rot. Further mechanistic analysis reveals that γ-mangostin treatment significantly disrupts DNA synthesis, impairs swimming motility, and induces marked alterations in Xcc cell morphology. CONCLUSION: We demonstrate for the first time that γ-mangostin exerts potent antibacterial activity by compromising cellular integrity and suppressing critical virulence functions in Xcc. These findings provide a molecular foundation for advancing γ-mangostin as a sustainable biocontrol agent against Xcc for the management of crucifer black rot disease. © 2025 Society of Chemical Industry.

Source: Pest Management Science

DOI: 10.1002/ps.70340