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Synthesis and evaluation of lupeol-derived triterpenic azines as potential neuroprotective agents

Year: 2025

Type: article

Abstract: New triterpenic azines from lupeol exhibited neuroprotective effects in vitro , with 4c notably preventing 6-OHDA- and ferroptosis-induced dopaminergic cell death, highlighting its potential for Parkinson's disease.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00753d

Authors: Florencia A. Musso, Natalia P. Alza, Gabriela A. Salvador, María Belén Faraoni

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Sur, Instituto de Investigaciones Bioquímicas de Bahía Blanca, CONICET-UNS

Language: English

Topic: Natural product bioactivities and synthesis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Sur, Agencia Nacional de Promoción Científica y Tecnológica

Awards: G107486871, G1525401051, G2690910699, G430788335, G4389771238, G8726250344

OpenAlex ID: W4416030963

FWCI:

Cites: 58

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