Work

Coexistence of Maturity-Onset Diabetes of the Young Type 3 (MODY 3) and Diabetic Ketoacidosis: A Report of a Rare Case

Year: 2025

Type: article

Abstract: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes often misclassified as type 1 or type 2 diabetes. We report a young woman initially diagnosed with type 1 diabetes following gestational hyperglycaemia. Autoimmune testing was negative, and genetic analysis confirmed an HNF1A mutation consistent with maturity-onset diabetes of the young type 3 (MODY 3). Despite sulfonylurea therapy, she required insulin and experienced recurrent diabetic ketoacidosis (DKA) due to poor adherence. Improved engagement and continuous glucose monitoring led to marked glycaemic improvement. This case highlights the diagnostic challenge of MODY presenting with DKA, a rare occurrence in this condition. Early genetic testing is essential for accurate diagnosis, personalised management, and family counselling.

Source: Cureus

DOI: 10.7759/cureus.96360

Authors: Daniel E Ekwueme, Kyi Sann, Mohammad M Rahman

Institution: Wrexham Maelor Hospital

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416031730