Work

Association Between Psoriasis Risk and Body Mass Index and Waist Circumference in Diabetes: A Population-Based Cohort Study

Year: 2025

Type: article

Abstract: BACKGROUND: Psoriasis is acknowledged for its association with diabetes and obesity. However, the comprehension of the correlation between obesity and psoriasis risk in individuals with diabetes remains limited. OBJECTIVE: We aimed to examine the association of body mass index and waist circumference (WC) with the risk of developing psoriasis in individuals with type 2 diabetes mellitus (T2DM). METHODS: This retrospective cohort study utilized nationwide data for exploratory analysis. A total of 2,480,489 participants, all diagnosed with T2DM, were included. RESULTS: Over a 6.77±1.69-year follow-up, 71,514 patients (2.88%) were diagnosed with psoriasis. Adjusting for multiple variables, the study revealed a J-shaped pattern association between BMI levels and the hazard ratio (HR) for psoriasis in patients with T2DM. A linear pattern relationship was observed regarding WC, with the highest WC group showing the most elevated HR (HR, 1.123; 95% confidence interval, 1.091-1.156). CONCLUSION: Understanding the relationship between psoriasis risk and obesity in diabetic individuals holds the potential to enhance the management of patients with T2DM.

Source: Annals of Dermatology

DOI: 10.5021/ad.25.142

Authors: Seungah Yoo, Kyungdo Han, Ji Hyun Lee

Institutions: The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, Soongsil University

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416055923