Work

Pulmonary Benign Metastasizing Leiomyoma in a Patient With a Concurrent Breast Tumor: A Diagnostic Challenge

Year: 2025

Type: article

Abstract: Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition in which histologically benign smooth muscle tumors occur in distant organs, most often the lungs. Although typically discovered incidentally, differentiating BML from metastatic malignancy can be challenging in real-world clinical settings. A 53-year-old woman with a history of hysterectomy for uterine leiomyoma presented with multiple pulmonary nodules and a cystic left breast lesion containing an irregular solid component. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography demonstrated no significant fluorodeoxyglucose (FDG) uptake in the pulmonary nodules but intense uptake in the cystic lesion of the left breast. Excisional biopsy of the breast revealed an intraductal papilloma, while video-assisted thoracoscopic biopsy of the lung nodules demonstrated benign smooth muscle proliferation positive for α-smooth muscle actin and estrogen receptor (ER), with a very low Ki-67 index, findings consistent with BML. This case illustrates the diagnostic challenge of distinguishing BML from metastatic malignancy in patients with concurrent lesions. Awareness of this entity and its characteristic low FDG uptake may help clinicians avoid unnecessary overtreatment and adopt an appropriate diagnostic strategy.

Source: Cureus

DOI: 10.7759/cureus.96392

Authors: Tomoyuki Araya, Toshiyuki Kita, Takayuki Higashi, Ryo Hara, Hazuki Takato

Institutions: Kanazawa Medical Center, National Hospital Organization

Language: English

Topic: Uterine Myomas and Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416059188