Human plasma-derived plasminogen replacement in type 1 plasminogen deficiency: a pediatric case with multisystemic manifestation
Year: 2025
Type: article
Study design: Case Report
Abstract: Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis.Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas named as ''ligneous conjunctivitis''.Local conjunctival use of fresh frozen plazma (FFP) in combination with other eye medications such as cyclosporin and artificial tear drops may relieve the symptoms.Topical treatment with plasminogen eye drop s is the most p romising treatment that is not yet available in Turkey.
Source: Blood Coagulation & Fibrinolysis
Authors: Deniz Koçak Göl, Veysel Gök, Ebru Yilmaz, Ekrem Ünal, Musa Karakükcü, Tülin Tiraje Celkan, Alper Özcan
Institutions: Erciyes University, Hasan Kalyoncu University, Liv Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416063704