Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)
Year: 2025
Type: article
Study design: Observational Study
Abstract: New diagnostic tests and alternative samples to diagnose tuberculosis in children are needed to tackle the diagnostic gap of pediatric tuberculosis. The Determine TB LAM Ag test in urine demonstrated sensitivity of 15.9% and specificity of 90.6%. Collecting the urine in adhesive bag was an independent risk factor for positivity (odds ratio, 11.38; P < .01).
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciaf525
Authors: Lucía Carratalà Castro, Shilzia Munguambe, Alexander Kay, Willy Ssengooba, Durbbin Mulengwa, Sozinho Acácio, Joanna Ehrlich, Andrew R DiNardo, Anca Vasiliu, Abigail Seeger, Edson Mambuque, Clement Gascua Adu-Gyamfi, Helton Timoteo, Christoph Lange, Sabine Hermans, Anna Mandalakas, Elisa López-Varela, Alberto L García-Basteiro
Institutions: Manhiça Health Research Centre, Barcelona Institute for Global Health, Universitat de Barcelona, Baylor College of Medicine, Baylor College of Medicine Children’s Foundation, Makerere University, Radboud University Nijmegen, Radboud University Medical Center, German Center for Infection Research, Research Center Borstel - Leibniz Lung Center, University of Lübeck, Amsterdam UMC Location University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416063832