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Coincidence of Autoimmune Diabetes Mellitus and Familial Partial Lipodystrophy

Year: 2025

Type: article

Abstract: Familial partial lipodystrophy (FPLD) is a rare genetic disorder leading to adipose tissue deficiency/redistribution and metabolic dysregulation with insulin resistance, diabetes mellitus, and dyslipidemia. Coincidence of FPLD and autoantibody-positive type 1 diabetes has not been published yet. We identified a female patient with the initial diagnosis of autoantibody-positive type 1 diabetes who developed severe insulin resistance with daily insulin doses up to 300 IU/d, acanthosis nigricans, polycystic ovary syndrome, hyperphagia, myalgia, and dyslipidemia. Since her phenotype was suspicious for FPLD, genetic testing was initiated. It revealed a heterozygous missense variant at hot spot codon c.1444 within Lamin A/C (LMNA) (p.Arg482Trp). Insulin resistance and hyperphagia improved during treatment with the glucagon-like peptide 1-receptor agonist semaglutide in addition to insulin therapy. Thus, we report about a patient with FPLD2 and concomitant type 1 diabetes. This case demonstrates that coincidence of these 2 severe metabolic dysregulations challenges diagnosis, management, and treatment but demands awareness in our health care system for rare endocrine diseases to improve quality of care.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luaf265

Authors: Michelle Krienke, Hartmut H J Schmidt, Janine Buettner, Susanne Tan, Isabell Schumann, Konstanze Miehle