Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities
Year: 2025
Type: article
Abstract: -induced toxicity in SH-SY5Y cells without cytotoxicity. Additionally, both compounds displayed high permeability in PAMPA and MDCK-MDR1 assays, indicating their potential to cross the blood-brain barrier and reach therapeutic targets. These findings highlight the potential of reviving COX-2 inhibitors as multitargeted therapeutic agents for AD, offering a promising strategy to address multiple pathological aspects of the disease, including neuroinflammation, amyloid aggregation, and tau pathology.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00802f
Institutions: German University in Cairo, University of Hertfordshire, University of Bari Aldo Moro, LUM Jean Monnet University, Chang Gung University, Chang Gung University of Science and Technology, Weill Cornell Medicine, Cairo University, University of Lincoln, Ming Chi University of Technology, National Yang Ming Chiao Tung University, Chang Gung Memorial Hospital, Taoyuan Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416065257