Year: 2025
Type: article
Study design: Case Report
Abstract: OBJECTIVES: Varicella-zoster virus (VZV) encephalitis is a rare but severe complication of VZV. Intravenous acycloviris the standard treatment, with the potential side effect of renal impairment that can complicate the therapeutic course and pose an obstacle to recovery. The development of novel antiviral drugs and the optimization of clinical management become an urgent necessity. METHODS AND RESULTS: We describe the first case of VZV encephalitis with intolerance to intravenous acyclovir that was successfully treated with oral brivudine monotherapy without discernible sequelae. CONCLUSION: Brivudine is a promising therapy for VZV encephalitis, particularly in cases intolerant to traditional antivirals or complicated by renal impairment.
Authors: Zhaozhao Shao, Feiying Guo, Shunli Tang
Institutions: Zhejiang Chinese Medical University, Huzhou Central Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W4416066113