Work

Autophagy-dependent modulation of ER calcium release drives KCNMA1/BKCa signaling and seizure susceptibility

Year: 2025

Type: article

Abstract: Macroautophagy/autophagy is best known for its role in maintaining cellular homeostasis through degradation of damaged proteins and organelles. In neurons, autophagy also contributes to the regulation of activity by adjusting the availability of cellular components to physiological demand. In a recent study, we show that autophagy shapes neuronal excitability by restraining a calcium-dependent pathway that couples endoplasmic reticulum calcium release to KCNMA1/BKCa activity at the plasma membrane. When autophagy is lost, this pathway is enhanced, and seizure susceptibility increases.

Source: Autophagy

DOI: 10.1080/15548627.2025.2580436

Authors: Gaga Kochlamazashvili, Marijn Kuijpers

Institutions: Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Deutsche Forschungsgemeinschaft, Lundbeckfonden, H. Lundbeck A/S