Work

Asymmetric Lip Hyperpigmentation in a Transplant Patient

Year: 2025

Type: article

Abstract: A 56-year-old patient presented to our dermatology clinic with asymmetric hyperpigmentation on her lower lip, which had developed over the previous six to twelve months. Her medical history included kidney and pancreas transplants, requiring chronic immunosuppression, and two lip filler injections with hyaluronic acid (HA). Clinical examination revealed irregular pigmented macules limited strictly to the lower lip. Histological analysis showed epidermal melanosis, pigmentary incontinence, solar elastosis, and amorphous dermal HA deposits, without evidence of melanocytic hyperplasia or granulomatous inflammation.

Source: Dermatopathology

DOI: 10.3390/dermatopathology12040041

Authors: Vincent Kimpe, David Alvarez Martinez, Sébastien Menzinger, Gürkan Kaya

Institution: University Hospital of Geneva

Language: English

Topic: melanin and skin pigmentation

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,810