Work

Hemizygous mutation of Jmjd3 in muscle stem cells increases H3K27 methylation on Pax7 leading to impaired myogenesis

Year: 2025

Type: article

Abstract: This investigation reveals a new mechanism that regulates the development of muscle. Mutating Jmjd3 produced epigenetic modifications to the transcription factor Pax7, reducing its expression and impairing muscle growth.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00681.2025

Authors: James G. Tidball, Lina Petrossian, Cynthia M. McKee, Michelle Wehling-Henricks

Institution: University of California, Los Angeles

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1528649053, G183243491, G3508371607, G4579162682, G5904733790, G7291660414, Myeloid-cell mediated mechanisms driving muscle growth and regeneration, Immune cell regulation of the regeneration of dystrophic muscle

OpenAlex ID: W4416075489

FWCI: 0.254

Cites: 45

Cited by: 1

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