Serum heparin binding protein as a biomarker for sepsis in pyogenic liver abscess patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Pyogenic liver abscess (PLA) is a severe infectious condition characterized by hepatic parenchymal pus accumulation, posing diagnostic and management challenges despite medical advances. Sepsis ensuing from PLA signifies a critical clinical scenario with notable morbidity and mortality implications. METHODS: A retrospective analysis encompassing 202 PLA patients over five years discerned 79 with sepsis (PLAS group) and 123 without sepsis (PLA group). Baseline characteristics, pathogen distribution, and serum heparin-binding protein (HBP) levels were assessed, alongside statistical analyses including multivariate logistic regression and receiver operating characteristic (ROC) curve analysis. RESULTS: Significant differences in biliary tract disease prevalence, plasma procalcitonin (PCT), and blood lactate levels were noted between PLAS and PLA groups, suggesting potential sepsis indicators in PLA patients. Klebsiella pneumoniae predominated among cultured pathogens, with no significant difference between septic and non-septic groups. Serum HBP levels were markedly elevated in PLAS patients, exhibiting positive correlations with sepsis severity and serving as an independent sepsis risk factor. ROC analysis demonstrated enhanced diagnostic performance for sepsis when combining serum HBP, PCT, and blood lactate levels. CONCLUSION: Serum HBP provides diagnostic and prognostic value for sepsis in PLA patients, and its combination with established biomarkers improves early detection and management.
Source: Biomarkers in Medicine
Authors: Caicai Zhang, Baoyong Zhang, Qishuang Song, Qiling Yin, Haixia Wang
Institution: Shandong First Medical University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416075947