Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers
Year: 2025
Type: article
Abstract: This study highlights key differences in acute ischemic responses between contracting and blebbistatin-treated noncontracting rabbit hearts. Contracting hearts showed faster, more severe action potential duration reductions, increased spatially discordant alternans, and steeper restitution slopes, emphasizing the role of mechanoelectric feedback and higher metabolic demands. These findings challenge reliance on noncontracting models in electrophysiological research, underscoring the need for models integrating mechanical and electrical dynamics to improve the translational relevance of ischemic studies.
Authors: Vineesh Kappadan, Zhen Hua, Paraskevas Efstathiou, Jan Lebert, Anies Sohi, Danya Agha-Jaffar, Johanna B. Tonko, Xianbo Sun, Najmah Mohamed, Yasser Abdelghani, Nicholas S. Peters, Jan Christoph, Fu Siong Ng
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416076163