Cerebral Blood Volume Index Is Associated with Futile Recanalization after Endovascular Thrombectomy in Anterior Circulation Large Vessel Occlusion Stroke
Year: 2025
Type: article
Study design: Observational Study
Abstract: ABSTRACT BACKGROUND AND PURPOSE: Endovascular thrombectomy (EVT) markedly improves outcomes in anterior circulation large vessel occlusion (LVO) stroke. The CBV index, derived from CTP as a marker of collateral circulation, has shown promise for prognosis. Still, its role in predicting futile recanalization remains unclear. This study evaluates the utility of the CBV index for identifying patients at risk of futile recanalization after EVT. MATERIALS AND METHODS: In this retrospective multi-center study, we assessed patients with anterior circulation LVO involving the intracranial ICA, M1, or proximal M2 segments who underwent EVT. Baseline CT perfusion was used to calculate the CBV index, defined as the ratio of mean CBV in the ischemic region (relative CBF <30% within Tmax >6 s) to the contralateral homologous area. Futile recanalization was defined as successful reperfusion (mTICI ≥2b) with poor functional outcome at 90 days (mRS 3–6). Nonparametric testing, ROC curve analysis, and uni-/multivariable logistic regression were performed. RESULTS: Among 162 patients, 81 (50%) experienced futile recanalization. CBV index was significantly lower in these patients compared with those with favorable outcomes (0.78 ± 0.16 vs. 0.82 ± 0.15; p = 0.04). ROC analysis identified a CBV index cutoff of 0.54 for predicting futile recanalization (accuracy 69%). On multivariable analysis, CBV index <0.70 independently predicted futile recanalization (p = 0.02) after adjustment for clinical and procedural variables. CONCLUSIONS: Lower CBV index is associated with increased risk of futile recanalization despite successful EVT. CBV index could be employed as an adjunct imaging biomarker to guide patient treatment planning and predict prognosis. ABBREVIATIONS: EVT＝ Endovascular Thrombectomy; LVO＝ Large Vessel Occlusion; AIS＝ Acute Ischemic Stroke; HIR＝Hypoperfusion Intensity Ratio; ROC＝ Receiver Operating Characteristic; AUC＝ Area Under the Curve; HT＝ Hemorrhagic Transformation; Tmax＝ Time-to-Maximum of the Tissue Residue Function; IVT＝ Intravenous thrombolysis; mTICI＝ modified Thrombolysis in Cerebral Infarction.
DOI: 10.3174/ajnr.a9096
Institutions: West Virginia University, The University of Texas MD Anderson Cancer Center, University of California, Los Angeles, University of California, San Francisco, Yale University, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Tehran University of Medical Sciences, University of Münster, University Hospital Münster, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Toronto Metropolitan University, Erasmus Hospital, Stanford Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G2957344627, G3430416378
OpenAlex ID: W4416082575