Work

Bioorthogonal Suzuki–Miyaura Cross-linking: Transforming Responsive Hydrogels into Permanent Polymer Networks

Year: 2025

Type: article

Abstract: In this study, we present a novel approach to convert reversible polymer networks into stable, nonresponsive networks using bio-orthogonal Suzuki-Miyaura coupling (SMC). By leveraging boronic acids, which form reversible boronate esters with cis-diols for shear-thinning injectable gels and serve as SMC substrates to create stable C-C bonds, we achieve switching from responsive to nonresponsive behavior. We demonstrate the concept with a responsive precursor based on sodium alginate modified with phenyl boronic acid, cross-linked with three model iodide-functionalized (macro-)molecules that exhibit irreversible gelation under bio-orthogonal conditions. The resulting networks exhibit robust mechanical stability, minimal pH and temperature responsiveness, high degradation resistance and excellent hemocompatibility. The proposed approach underlines the potency of SMC as a robust synthetic strategy toward the synthesis and transformation of polymer networks for advanced biomedical applications.

Source: Biomacromolecules

DOI: 10.1021/acs.biomac.5c01053

Authors: Anastasia Anagnostou, George Pasparakis

Institution: University of Patras

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: University of Patras