Year: 2025
Type: article
Abstract: Unity Simulation Manager, a software application based on large language models (LLMs), is designed to generate C# scripts simulating three-dimensional colonies of model organisms, including Escherichia coli and Saccharomyces cerevisiae, within the Unity platform. The system, which utilizes fine-tuned LLMs, translates descriptions of desired simulations (organizations, growth rates, and appearance) in natural language into functional C# code. The coupling of artificial intelligence with biological simulation generates intricate dynamics to be simulated. The approach involves using a dual-LLM pipeline (one computing user requests, the other generating some code for Unity DOTS), with the goal of making 3D simulation development more democratized. It provides a scalable, customizable option, particularly for users lacking sophisticated programming skills, decreasing manual coding effort and time. This work explains the pipeline architecture, fine-tuning process, and demonstrates the system to produce functional, scalable simulations successfully scaling up to cases with more than one million organisms.
Source: ACS Synthetic Biology
Institution: Universidad Diego Portales
Language: English
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $4,500
OpenAlex ID: W4416094246