Nucleophile Promoted Functionalization of Cross‐Conjugated Enynone Gives Sulfonylated Furan
Year: 2025
Type: article
Abstract: Serendipitous formation of sulfonylated furan was observed when cross‐conjugated sulfonyl enynones were reacted under basic conditions in alcohol, with solvent acting as a nucleophile. Fluorinated alcohols gave the best outcomes. Not only alcohols but other nucleophiles also worked well via Michael addition/alkyne to allene isomerization/ oxa ‐Michael addition reaction sequence. The developed protocol is extended to the synthesis of pyrrole, benzofuran, and polyheterocyclic compounds. The TFE‐substituted sulfonylated furan can be easily transformed into bi‐/triaryl methanes.
Source: Advanced Synthesis & Catalysis
DOI: 10.1002/adsc.70209
Authors: Santosh J. Gharpure, Shipra Somani
Institution: Indian Institute of Technology Bombay
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4416094478