Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Introduction: Understanding the neural mechanisms underlying decision-making under uncertainty represents a fundamental challenge in cognitive neuroscience. This meta-analysis aimed to identify the consistent neural correlates of uncertainty processing specifically during decision-making tasks. Methods: = 4,186 participants). Using the Activation Likelihood Estimation (ALE) method, we performed a voxel-wise meta-analysis of activation foci to identify brain regions consistently activated across studies. Results: The analysis revealed nine distinct activation clusters, revealing a comprehensive neural network involved in uncertainty processing. Key findings demonstrated predominant activations in the anterior insula (up to 63.7% representation), inferior frontal gyrus (up to 40.7%), and inferior parietal lobule (up to 78.1%). We found a functional specialization between emotional-motivational processes (clusters 1-5) and cognitive processes (clusters 6-9), with notable hemispheric asymmetries. The left anterior insula was more strongly associated with reward evaluation, while the right was involved in learning and cognitive control. Similarly, the right inferior frontal gyrus was linked to impulse control, and the left to motor planning. Discussion: Our findings extend the current understanding of the neural architecture of decision-making under uncertainty. The comprehensive mapping of neural signatures advances our knowledge of the distinct roles of key brain regions and provides insights into potential clinical applications, particularly for developing interventions for uncertainty-related anxiety. The study highlights important directions for future research in cognitive neuroscience and clinical practice.
Source: Frontiers in Neuroscience
Authors: Andrey Timashkov, Sarah Anderson, Oksana Zinchenko
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416099214