Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy
Year: 2025
Type: article
Abstract: Photosensitizing systems based on methylene blue (MB)-loaded calcium alginate (CaA) and alginic acid (AA) aerogels were developed for photodynamic therapy of difficult-to-heal wounds. Hybrid aerogels incorporating polyvinylpyrrolidone (PVP, 2.5–40 wt%) into CaA and AA matrices were also made. The MB release kinetics in a phosphate buffer were found to depend on the aerogel type (AA or CaA). The incorporation of PVP increased the MB release rate by 1.5–2 times. The singlet oxygen ( 1 O 2 ) generation efficiency of MB embedded in the aerogels was influenced by their porosity and chemical composition. The activity of MB in the photogeneration of 1 O 2 increased by up to four times in the PVP-containing aerogels. Furthermore, the photoactivity of MB in the hybrid aerogel matrices significantly exceeded that in the single-component alginate aerogels.
Source: Frontiers in Chemistry
Authors: Ilya Shershnev, Anna Solovieva, Alexander Kopylov, Anastasiya Cherkasova, Vladislav Kaplin, Sergey Rachev, Anastasiya Kuryanova, Nadezhda Aksenova, Victoriya Timofeeva, Anastasiya Akovantseva, Tatyana Zarkhina, Viktor Shantarovich, Valentin Bekeshev, Polina Bikmulina, Ru-Lin Huang, Qingfeng Li, Peter Timashev
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Russian Science Foundation
Award: G2481844429
OpenAlex ID: W4416099253